Why Joint Aches Occur with B12 Supplementation When joint discomfort does arise in temporal association with vitamin B12 therapy, several possible explanations may be considered, though none represent a direct toxic or pharmacological effect of cobalamin itself
Take whatever approach works best for your situation
Have difficulty absorbing B12 through food or supplements
Still, side effects from B12 supplements are possible, especially at higher doses, and include: Headache Nausea Vomiting Fatigue Weakness Diarrhea Tingling in the hands and feet Nasal spray Vitamin B12 is also available in a nasal spray
Regarding FDA approval: because this is a compounded product, it is not directly FDA-approved
Pregnancy, breastfeeding and cyanocobalamin